Biochemistry and Molecular Biology
Penn State Science
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Andrew D. Patterson

Andrew D. Patterson

Main Content

  • Tombros Early Career Professor
  • Associate Professor of Molecular Toxicology
  • Associate Professor of Biochemistry & Molecular Biology
322 Life Sciences Bldg
University Park, PA 16802
Phone: (814) 867-4565

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Graduate Programs

BMMB, MCIBS, PATHB

Areas of Expertise

Metabolomics
Microbiome
Drug Metabolism
Metabolism
Environmental Contaminants

Connect with Andrew Patterson, Ph.D.

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Education

Research Fellow, National Cancer Institute (NCI), 2006-2011
Pharmacology Research Associate in Training Fellow, National Institute of General Medical Sciences (NIGMS), 2006-2009
PhD, Genetics, Graduate Partnerships Program, NCI and George Washington University, 2006
BS, Microbiology, Penn State University, 1999
 

Research Summary

The Patterson lab students, postdocs, and collaborators focus on understanding the host-metabolite-microbiota communication network—specifically how the manipulation of gut microbiota by diet and/or xenobiotics impacts host metabolites (e.g., bile acids, short chain fatty acids), their metabolism, and how these co-metabolites interact with host nuclear/soluble receptors (e.g., farnesoid X receptor, aryl hydrocarbon receptor). The lab employs a variety of tools, including NMR- and mass spectrometry-based metabolomics, genomics, and conventional and gnotobiotic transgenic mice, to facilitate its study of these pathways and understand their impact on human health and disease.  

Selected Publications

2018 (for full list please see Google Scholar page)
 

1.     S.A. Bora, M.J. Kennett, P.B. Smith, A.D. Patterson, M.T. Cantorna. Regulation of vitamin D metabolism following disruption of the microbiota using broad spectrum antibiotics. J Nutr Biochem. 2018 Feb 2;56:65-73. doi:10.1016/j.jnutbio.2018.01.011. [Epub ahead of print] PubMed PMID: 29459310.

2.     Y. Tian, R.G. Nichols, J. Cai, A.D. Patterson, M.T. Cantorna. Viatmin A deficiency in mice alters host and microbial metabolism leading to altered energy homeostasis. J Nutr Biochem. 2018 54:28-34. doi.org/10.1016/j.jnutbio.2017.10.011.

3.     K.R. Belton, Y. Tian, L. Zhang, M. Anitha, P.B. Smith, G.H. Perdew, A.D. Patterson. Metabolomics Reveals Aryl Hydrocarbon Receptor Activation Induces Liver and Mammary Gland Metabolic Dysfunction in Lactating Mice. J Proteome Res. 2018 Mar 9. doi: 10.1021/acs.jproteome.7b00709. [Epub ahead of print] PubMed PMID:29521512.

4.     P. Pathak, X. Cen, R.G. Nichols, J.M. Ferrell, S. Boehme, K.W. Krausz, A.D. Patterson, F.J. Gonzalez, J.Y.L. Chiang. Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism. Hepatology. 2018 Feb 27. doi: 10.1002/hep.29857. [Epub ahead of print] PubMed PMID: 29486523.

5.     A. Dey, J.N. Allen, J.W. Fraser, L.M. Snyder, Y. Tian, L. Zhang, R.F. Paulson. A.D. Patterson, M. T. Cantorna, P. A. Hankey-Giblin. Neuroprotective role of the RON receptor tyrosine kinase underlying CNS inflammation in health and disease. Frontiers in Immunology 2018 9:513. doi: 10.3389/fimmu.2018.00513

6.     S.A. Bora, M.J. Kennett, P.B. Smith, A.D. Patterson, M.T. Cantorna. The gut microbiota regulates endocrine vitamin D metabolism through fibroblast growth factor 23. Frontiers in Immunoloy 2018 9:408 https://doi.org/10.3389/fimmu.2018.00408.

7.     J. Allen, J. Zhang, M.D. Quickel, M. Kennett, A.D. Patterson, P.A. Hankey-Giblin. Ron Receptor Signaling Ameliorates Hepatic Fibrosis in a Diet-Induced Nonalcoholic Steatohepatitis Mouse Model. J Proteome Res. 2018 Sep 7;17(9):3268-3280. doi:10.1021/acs.jproteome.8b00379. Epub 2018 Aug 23. PubMed PMID: 30091925.

8.     H. Waghulde, X. Cheng, S. Galla, B. Mell, J. Cai, S.M. Pruett-Miller, G. Vazquez, A.D. Patterson, M. Vijay Kumar, B. Joe. Attenuation of Microbiotal Dysbiosis and Hypertension in a CRISPR/Cas9 Gene Ablation Rat Model of GPER1. Hypertension In press.

9.     L. Sun, C. Xie, G. Wang, Y. Wu, Q. Wu, X. Wang, J. Liu, Y. Deng, J. Xia, B. Chen, S. Zhang, C. Yun, G. Lian, X. Zhang, H. Zhang, W.H. Bisson, J. Shi, X. Gao, P. Ge, C. Liu, K.W. Krausz, R.G. Nichols, J. Cai, B. Rimal, A.D. Patterson, X. Wang, F.J. Gonzalez, C. Jiang. Metabolic Benefits of Metformin Rely on Its Alterations of the Gut Microbiota and Intestinal FXR Signaling. Nature Medicine In press.

10.  R.G. Nichols, J. Cai, I.A. Murray, I. Koo, P.B. Smith, G.H. Perdew, A.D. Patterson. Structural and Functional Analysis of the Gut Microbiome for Toxicologists. Curr Protoc Toxicol. 2018 Sep 19:e54. doi: 10.1002/cptx.54. [Epub ahead of print] PubMed PMID: 30230220.

11.  M. Cheema M, P.B. Smith, A.D. Patterson, A. Hristov, F.M. Harte. The association of lipophilic phospholipids with native bovine casein micelles in skim milk: Effect of lactation stage and casein micelle size. J Dairy Sci. 2018 Oct;101(10):8672-8687. doi: 10.3168/jds.2017-14137. Epub 2018 Jul 19. PubMed PMID: 30031576.

12.  V. Singh, B.S. Yeoh, B. Chassaing, X. Xiao, P. Saha, R. O. Olvera, J.D. Lapek, Jr., L. Zhang, W.B. Wang, S. Hao, M. D. Flythe, D.J. Gonzalez, P.D. Cani, J. R. Conejo-Garcia, N. Xiong, M.J. Kennett, B. Joe, A.D. Patterson, A.T. Gewirtz, M. Vijay-Kumar. Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer. Cell In press.

13.  J. Cai, R.G. Nichols, I. Koo, Z. Kalikow, L. Zhang, Y. Tian, J. Zhang, P.B. Smith, A.D. Patterson. Multi-Platform Physiologic and Metabolic Phenotyping Reveals Microbial Toxicity. mSystems In press.

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