Biochemistry and Molecular Biology
Penn State Science
You are here: Home Directory Frank Dorman
Frank  Dorman

Frank Dorman

Main Content

  • Associate Professor of Biochemistry and Molecular Biology
240 Chemistry Building (Mail: 107 Althouse)

University Park, PA 16802
Phone: (814) 863-6805

Dr. Frank Dorman's research interests fall loosely into two categories:

Fundamental studies into chromatographic separations and applied chromatographic separation of trace compounds in complex matrices. In this capacity, Dr. Dorman's laboratory focuses mainly on the techniques of Gas Chromatography (GC) and Liquid Chromatography (HPLC) often coupled with Mass Spectrometry (MS) as the detection type. Dr. Dorman also utilized multidimensional gas chromatography (GCxGC) coupled with both selective detection and mass spectrometry. This technique, relatively new to separations science, is capable of very complex separations, and Dr. Dormans research laboratory was the group that first worked on the development of the commercially-available instrument sold by Leco Corporation today. Various sample preparation techniques are also active research areas in Dr. Dormans laboratory, including automated techniques that allow for high sample throughput which is necessary for studies where statistical trends are to be determined.

Fundamental Research projects include:

1.) The development of new format GC and HPLC columns.

2.) The development of new chromatographic stationary phase chemistries through the use of molecular mechanics and thermodynamic modeling.

3.) Optimization of chromatographic separations through the use of thermodynamic modeling.

4.) Continued development of GCxGC in terms of the understanding and optimization of the technique, and continued application of this technique to difficult sample analysis.

Applied research projects include:

1.) Development of novel sample preparation techniques for the analysis of various categories of compounds in human fluids.

2.) Environmental forensic separations including persistent organic pollutants.

3.) Improvements in environmental separations to achieve better resolution and detectability

4.) Development of metabolomic profiling methodologies in both animal and plant species, and coupling these techniques to the possible discovery of the relationship of exposure to expressed disease state in these species.