Dr. Frank Dorman's research interests fall loosely into two categories:
Fundamental studies into chromatographic separations and applied
chromatographic separation of trace compounds in complex matrices. In
this capacity, Dr. Dorman's laboratory focuses mainly on the techniques
of Gas Chromatography (GC) and Liquid Chromatography (HPLC) often
coupled with Mass Spectrometry (MS) as the detection type. Dr. Dorman
also utilized multidimensional gas chromatography (GCxGC) coupled with
both selective detection and mass spectrometry. This technique,
relatively new to separations science, is capable of very complex
separations, and Dr. Dormans research laboratory was the group that
first worked on the development of the commercially-available
instrument sold by Leco Corporation today. Various sample preparation
techniques are also active research areas in Dr. Dormans laboratory,
including automated techniques that allow for high sample throughput
which is necessary for studies where statistical trends are to be
Fundamental Research projects include:
1.) The development of new format GC and HPLC columns.
2.) The development of new chromatographic stationary phase
chemistries through the use of molecular mechanics and thermodynamic
3.) Optimization of chromatographic separations through the use of thermodynamic modeling.
4.) Continued development of GCxGC in terms of the understanding and
optimization of the technique, and continued application of this
technique to difficult sample analysis.
Applied research projects include:
1.) Development of novel sample preparation techniques for the analysis of various categories of compounds in human fluids.
2.) Environmental forensic separations including persistent organic pollutants.
3.) Improvements in environmental separations to achieve better resolution and detectability
4.) Development of metabolomic profiling methodologies in both animal
and plant species, and coupling these techniques to the possible
discovery of the relationship of exposure to expressed disease state in