Biochemistry and Molecular Biology
Penn State Science
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Jeffrey Peters, Ph.D., A.T.S

Jeffrey Peters, Ph.D., A.T.S

Main Content

  • Distinguished Professor of Molecular Toxicology & Carcinogenesis
  • Deputy Director, The Penn State Cancer Institute
312 Life Sciences Building
University Park, PA 16802
Email: jmp21@psu.edu
Phone: (814) 863-1387

Research Summary

Our laboratory studies the role of the peroxisome proliferator-activated receptors (PPARs) in the regulation of homeostasis, toxicology and carcinogenesis. PPARs are members of the nuclear receptor superfamily and are critical modulators of environmental and dietary stimulii. For example fatty acids and metabolic derivatives of fatty acids derived primarily from dietary sources are known ligands that can activate PPARs. Moreover, environmental chemicals can also activate PPARs, such as perfluorinated chemicals and phthalate monesters that are currently a major health concern. Acting as regulatory transcription factors, the PPARs modulate gene expression of target genes containing peroxisome proliferator responsive elements in response to ligand activation. Numerous genes that modulate lipid metabolism are regulated by PPARα, PPARβ/δ and PPARγ ligands/activators, and are clinically relevant for a number of diseases including diabetes, obesity, atherosclerosis and cancer. In addition to transcriptional regulation, PPARs can also epigenetically regulate transcription by interacting with other proteins including NF-κB. Our laboratory uses “knockout”, transgenic mouse models, and high affinity agonists, antagonists, and selective, repressive ligands to delineate the roles of PPARs, with a particular interest in epithelial and liver cancer. Through our studies, we are elucidating the molecular mechanisms by which exogenous (dietary) and endogenous (metabolic sources) lipids specifically modulate human health. We are particularly interested in delineating how natural compounds found in dietary constituents can activate PPARs with the goal of identifying new molecules/proteins that can be targeted with existing approaches to improve the efficacy of chemoprevention and chemotherapy. Our studies will likely lead to the identification of specific macronutrients that will effectively activate PPARs so that dietary formulations of agricultural products can be developed that will improve human and animal health and prevent serious diseases.

Research Interests

Molecular Toxicology & Carcinogenesis Research Faculty

Roles of peroxisome proliferator-activated receptors (PPARs) in the regulation of homeostasis, toxicology, and carcinogenesis.

 

Graduate Programs

  • Molecular Cellular Integrative Biosciences (MCIBS)
  • Biochemistry, Microbiology and Molecular Biology
  • Pathobiology

 

Honors and Awards

•The Huck Award for Outstanding Achievements in Life Sciences Research, 2016
•Gamma Sigma Delta Faculty Research Award, 2016
•Fellow, Academy of Toxicological Sciences, 2012-present
•Faculty of 1000, Pharmacology and Drug Discovery Faculty, 2011-present
•National Institutes of Health Director's Wednesday Afternoon Lecture, 2009
•Society of Toxicology Achievement Award, 2007
•Black Award for Excellence in Research, College of Ag. Sciences, Penn State University, 2007
•Teratology Society F. Clarke Fraser New Investigator Award, March 2002

Selected Publications

Publications

Google Scholar Website can be found here.

 

Book Chapters

  • Peters, J.M. and Vanden Heuvel, J.P. Peroxisome Proliferators. In: Cellular and Molecular Toxicology (Greenlee, W.F., Perdew, G.H., Mattes, W. and Vanden Heuvel, J.P. eds.) Elsevier Science Inc., New York, NY (2002) pp. 133-158.
  • Peters, J.M. Use of transgenic and knockout mice to study gene regulation. In: Regulation of Gene Expression (Perdew, G.H., Vanden Heuvel J.P. and Peters, J.M. eds.) Humana Press, Totowa, NJ (2006) pp. 267-321.
  • Perdew, G.H., Murray, I.A. and Peters, J.M. Xenobiotic receptor-mediated toxicity. In: Comprehensive Toxicology (McQueen, C. ed.) Oxford: Academic Press, (2010) pp. 361-388.
  • Peters, J.M. and Gonzalez, F.J. Regulation of cell proliferation, differentiation and inflammatory signaling by peroxisome proliferator-activated receptor-β/δ (PPARβ/δ). In: Xenobiotic Metabolizing Enzymes and Xenobiotic Receptors. Pharmacological and Toxicological Aspects (Elizondo, G. ed.) Research Signpost, Kerala, India (2009).
  • Peters, J.M. and Gonzalez, F.J. Regulation of squamous cell carcinoma carcinogenesis by peroxisome proliferator-activated receptors (PPARs) pp 223-240. In: Signaling Pathways in Squamous Cancer (Glick, A.B. and van Waes, C. eds.) Springer, New York, NY (2011).
  • Perdew, G.H., Murray, I.A., Patterson, A.D. and Peters, J.M. Mechanisms: Xenobiotic receptor-mediated toxicity. In: Comprehensive Toxicology (McQueen, C. ed.) Oxford: Academic Press, (2016) doi.org/10.1016/B978-0-12-801238-3.64105-3

Journal Articles

  • Corton, J.C., Peters, J.M. and Klaunig, J.E.. The PPARα-dependent rodent liver tumor response is not relevant to humans: Addressing misconceptions. Archives of Toxicology (2018) 92: 83-119.
  • Bagley, B.D., Chang, S.-C., Ehresman, D.J., Eveland, A., Parker, G.A., Peters, J.M. and Butenhoff, J.L. Four Week dietary supplementation with 10- and/or 15-fold basal choline caused decreased body weight in Sprague Dawley rats. Toxicology and Industrial Health (2017) 33: 792-801.
  • Bagley, B.D., Chang, S.-C., Ehresman, D.J., Eveland, A., Zitzow, J., Parker, G.A., Zehowski, C., Peters, J.M., Wallace, K.B. and Butenhoff, J.L.. Perfluorooctane sulfonate-induced hepatic steatosis in male Sprague Dawley rats is not attenuated by choline supplementation. Toxicological Sciences (2017) 160: 284-298.
  • Peters, J.M.. Flipping a citrate switch on liver cancer cells. The Journal of Biological Chemistry (2017) 292: 13902-13903.
  • Borland, M.G., Yao, P.-L., Kehres, E.M., Lee, C., Pritzlaff, A.M., Ola, E., Wagner, A.L., Shannon, B.E., Albrecht, P.P., Zhu, B., Kang, B.-H., Robertson, G.P., Gonzalez, F.J., and Peters, J.M.. PPARβ/δ and PPARγ inhibit melanoma tumorigenicity by modulating inflammation and apoptosis. Toxicological Sciences (2017) 159: 436-448. (EDITOR’S HIGHLIGHT).
  • Yao, P.-L., Morales, J.L., Gonzalez, F.J. and Peters, J.M. Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) regulates mast cell growth and differentiation. Immunology (2017) 150: 456-467.
  • Yao, P.-L., Chen, L., Dobrzański, T.P., Zhu, B., Kang, B.-H., Müller, R., Gonzalez, F.J., Singh, U.S. and Peters, J.M. Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) inhibits human neuroblastoma cell tumorigenesis by p53- and SOX2-mediated cell differentiation. Molecular Carcinogenesis (2017) 56: 1472-1483.
  • Allen, J.N., Dey, A., Nissly, R., Balandaram, G., Peters, J. and Hankey-Giblin, P.A. Isolation, characterization, and purification of macrophages from tissues affected by obesity-related inflammation. Journal of Visualized Experiments (2017) 122: e55445, doi:10.3791/55445.
  • Koga, T., Yao, P.-L., Goudarzi, M., Murray, I. A., Balandaram, G., Gonzalez, F.J., Perdew, G.H., Fornace Jr., A.J. and Peters, J.M.. Novel regulation of cytochrome P450 2B10 (CYP2B10) expression in liver by peroxisome proliferator-activated receptor-β/δ (PPARβ/δ). The Journal of Biological Chemistry (2016) 291: 25255-25263.
  • Nichols, R.G., Hume, N.E., Smith, P.B., Peters, J.M. and Patterson, A.D.. Omics approaches to probe microbiota and drug metabolism interactions. Chemical Research in Toxicology (2016) 29: 1987-1997.
  • Choudary, M., Ding, J., Qi, X., Boulton, M.E., Yao, P.-L., Peters, J.M. and Malek, G.. Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) selectively regulates phenotypic features of age-related macular degeneration. Aging (2016) 8: 1952-1971.
  • Balandaram, G., Kramer, L.R., Kang, B.-H., Murray, I.A., Perdew, G.H., Gonzalez, F.J. and Peters, J.M.. Ligand activation of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) attenuates hepatocarcinogenesis in hepatitis B transgenic mice. Toxicology (2016) 363: 1-9.
  • Zhang, L., Krishnan, P., Ehresman, D.J., Smith, P.B., Bagley, B. D., Chang, S.-C., Butenhoff, J.L., Patterson, A.D. and Peters, J.M.. Perfluorooctanesulfonate-choline ion pair formation: a potential mechanism for perfluorooctanesulfonate-induced liver toxicity in mice. Toxicological Sciences (2016) 153: 186-197 (EDITOR’S HIGHLIGHT).
  • Yu, S., Allen, J.N., Dey, A., Zhang, L., Balandaram, G., Kennett, M.J., Xia, M., Xiong, N., Peters, J.M., Patterson, A.D. and Hankey, P.A.. The Ron receptor tyrosine kinase regulates macrophage heterogeneity and plays a protective role in diet-induced obesity, atherosclerosis and hepatosteatosis. Journal of Immunology (2016) 197: 256-265.
  • Peters, J.M., Gonzalez, F.J. and Müller, R.. Establishing the role of PPARβ/δ in carcinogenesis. Trends in Endocrinology and Metabolism (2015) 595-607. Cover page article.
  • Yao, P.-L., Chen, L.-P., Dobrzanski, T.P., Phillips, D.A., Zhu, B., Kang, B.-H., Gonzalez, F.J. and Peters, J.M.. Inhibition of testicular embryonal carcinoma cell tumorigenicity by peroxisome proliferator-activated receptor-β/δ- and retinoic acid receptor-dependent mechanisms. Oncotarget (2015) 36319-36337.
  • Yao, P.-L., Chen, L.-P., Hess, R.A., Müller, R., Gonzalez, F.J. and Peters, J.M.. Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) coordinates mouse spermatogenesis by modulating ERK-dependent signaling. The Journal of Biological Chemistry (2015) 290: 23416-23431.
  • Park, J., Lee, S.E., Hur, J., Hong, E.B., Choi, J.-I., Yang, J.-M., Kim, J.-Y., Kim, Y.-C., Cho, H.-J., Peters, J.M., Ryoo, S.-B., Kim, Y.T. and Kim, H.-S. M-CSF from cancer cells induces fatty acid synthase and PPARβ/δ activation in tumor myeloid cells, leading to tumor progression. Cell Reports (2015) 10: 1614-1625.
  • Peters, J.M., Yao, P.-L., and Gonzalez, F.J.. Targeting peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) for cancer chemoprevention. Current Pharmacology Reports (2015) 1: 121-128.
  • Yao, P.-L., Ehresman, D.J., Caverly-Rae, J.M., Chang, S.-C., Frame, S.R., Butenhoff, J.L, Kennedy, G.L and Peters, J.M.. Comparative in vivo and in vitro analysis of possible estrogenic effects of perfluorooctanoic acid. Toxicology (2014) 326: 62-73.
  • Zhu, B., Ferry, C.H., Markell, L.M., Blazanin, N., Glick, A.B., Gonzalez, F.J. and Peters, J.M.. The nuclear receptor PPARβ/δ promotes oncogene-induced cellular senescence through repression of endoplasmic reticulum stress. The Journal of Biological Chemistry (2014) 289: 20102-20119.
  • Borland, M.G., Krishnan, P. Lee, C., Albrecht, P.P., Shan, W., Bility, M.T., Marcus, C.B., Lin, J.-M., Amin, S., Gonzalez, F.J., Perdew, G.H. and Peters, J.M.. Modulation of aryl hydrocarbon receptor (AhR)-dependent signaling by peroxisome proliferator-activated receptor-ß/d (PPARß/d) in keratinocytes. Carcinogenesis (2014) 35: 1602-1612.
  • Yao, P.-L., Morales, J.L.,  Zhu, B., Kang, B.-H., Gonzalez, F.J. and Peters, J.M.. Activation of peroxisome proliferator-activated receptor-ß/d (PPARß/d) inhibits human breast cancer cell line tumorigenicity. Molecular Cancer Therapeutics (2014) 1008-1017.
  • Corton, J.C., Cunningham, M.L., Hummer, B.T., Lau, C., Meek, B., Peters, J.M., Popp, J.A., Rhomberg, L., Seed, J. and Klaunig, J.E.. Mode of action framework analysis for receptor-mediated toxicity: the Peroxisome Proliferator-Activated Receptor alpha (PPARα) as a case study. Critical Reviews in Toxicology (2014) 44: 1-49.
  • Lahoti, T.S., Hughes, J.M., Kusnadi, A., John, K., Zhu, B., Murray, I.A., Gowda, K., Peters, J.M., Amin, S.G. and Perdew, G.H.. Aryl hydrocarbon receptor (AHR) attenuates growth factor expression, proliferation, and migration in fibroblast-like synoviocytes from patients with rheumatoid arthritis. Journal of Pharmacology and Experimental Therapeutics (2014) 348: 236-245.
  • Yao, P.-L., Gonzalez, F.J., and Peters, J.M.. Targeting estrogen receptor-ß (ERß) for the prevention of non-melanoma skin cancer. Cancer Prevention Research (2014) 7: 182-185.
  • Zhu, B., Bility, M.T., Ferry, C.H., Khozoie, C., Blazanin, N., Kang, B.-H., Glick, A.B., Gonzalez, F.J. and Peters, J.M.. PPARβ/δ promotes HRAS-induced senescence and tumor suppression by potentiating p-ERK and repressing p-AKT signaling. Oncogene (2013) doi: 10.1038/onc.2013.477.
  • Goudarzi, M., Koga, T., Khozoie, C., Mac, T.D., Kang, B.-H., Fornace, Jr., A.J. and Peters, J.M.. PPARβ/δ modulates ethanol-induced hepatic effects by decreasing pyridoxal kinase activity. Toxicology (2013) 311: 87-98.
  • Ito, S., Satoh, J., Matsubara, T., Shah, Y., Ahn, S., Anderson, C.R., Obata, T., Shan, W., Peters, J.M., and Gonzalez, F.J.. Cholestasis induces reversible accumulation of periplakin in mouse liver. BMC Gastroenterology (2013) 13: 116.
  • Albrecht, P.P., Torsell, N.E., Krishnan, P., Ehresman, D.J., Frame, S.R., Chang, S.-C., Butenhoff, J.L., Kennedy, G.L., Gonzalez, F.J. and Peters, J.M.. A species difference in the peroxisome proliferator-activated receptor a (PPARα)-dependent response to the developmental effects of perfluorooctanoic acid. Toxicological Sciences (2013) 131: 568-582.
  • Montanez, J.E., Peters, J.M., Correll, J.B., Gonzalez, F.J. and Patterson, A.D.. Metabolomics: An essential tool to understand the function of peroxisome proliferator-activated receptor alpha. Toxicologic Pathology (2013) 41: 410-418.
  • Zhu, B., Khozoie, C., Bility, M.T., Ferry, C.H., Blazanin, N., Glick, A.B., Gonzalez, F.J. and Peters, J.M.. Peroxisome proliferator-activated receptor-β/δ crosstalks with E2F and attenuates mitosis in HRAS-expressing cells. Molecular and Cellular Biology (2012) 32: 2065-2082.
  • Monk, J.M., Kim, W., Callaway, E., Turk, H.F., Foreman, J.E., Peters, J.M., He, W., Weeks, B., Alaniz, R.C., McMurray, D.N. and Chapkin, R.S.. Immunomodulatory action of dietary fish oil and targeted deletion of intestinal epithelial cell PPARδ in inflammation-induced colon carcinogenesis. American Journal of Physiology (2012) 302: G153-G167.
  • Peters, J.M., Shah, Y.M. and Gonzalez, F.J.. The role of peroxisome proliferator-activated receptors in carcinogenesis and chemoprevention. Nature Reviews Cancer (2012) 181-195.
  • Peters, J.M., Foreman, J.E. and Gonzalez, F.J.. Dissecting the role of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) in colon, breast and lung carcinogenesis. Cancer and Metastasis Reviews (2011) 30: 619-640.
  • Peters, J.M., Morales, J.L. and Gonzalez, F.J.. Modulation of gastrointestinal inflammation and colorectal tumorigenesis by peroxisome proliferator-activated receptor-β/δ (PPARβ/δ). Drug Discovery Today: Disease Mechanisms (2011) 8: e85-e93.
  • Peters, J.M. and Gonzalez, F.J.. Why Toxic Equivalency Factors are not Suitable for Perfluoroalkyl Chemicals. Chemical Research in Toxicology (2011) 24: 1601-1609.
  • Patterson, A.D. and Peters, J.M.. PPAR action in insulin resistance unraveled by metabolomics: potential clinical implications. Genome Medicine (2011) 3: 54.
  • Borland, M.B., Khozoie, C., Albrecht, P.P., Zhu, B., Lee, C., Lahoti, T.S., Gonzalez, F.J. and Peters, J.M.. Stable over-expression of PPARβ/δ and PPAR? to examine receptor signaling in human HaCaT keratinocytes. Cellular Signaling (2011) 23: 2039-2050.
  • Foreman, J.E., Chang, W.-C., Palkar, P.S., Zhu, B., Borland, M.G., Williams, J.L., Kramer, L.R., Clapper, M.L., Gonzalez, F.J. and Peters, J.M.. Functional characterization of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) in colon cancer. Molecular Carcinogenesis (2011) 50: 884-900.
  • Daoudi, M., Hennuyer, N., Borland, M.G., Touche, V., Duhem, C., Gross, B., Caiazzo, R., Kerr-Conte, J., Pattou, F., Peters, J.M., Staels, B. and Lestavel, S.. PPARβ/δ activation induces enteroendocrine L cell GLP-1 production. Gastroenterology (2011) 140: 1564-1574.
  • Omiecinski, C.J., Vanden Heuvel, J.P., Perdew, G.H. and Peters, J.M.. Xenobiotic metabolism, disposition and regulation by receptors: From biochemical phenomenon to predictors of major toxicities. Toxicological Sciences (2011) 120: S49-S75.
  • McGarver, G., Bhatia, J., Chambers, C., Clarke, R., Etzel, R., Foster, W., Hoyer, P., Leeder, J.S., Peters, J.M., Rissman, E., Rybak, M., Sherman, C., Toppari, J. and Turner, K.. NTP-CERHR expert panel report on the developmental toxicity of soy infant formula. Birth Defects Research-Part B (2011) 92: 421-468.
  • Zhu, B., Bai, R., Kennett, M.J., Kang, B.-H., Gonzalez, F.J. and Peters, J.M.. Chemoprevention of chemically induced skin tumorigenesis by ligand activation of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) and inhibition of cyclooxygenase 2 (COX2). Molecular Cancer Therapeutics (2010) 9: 3267-3277.
  • Palkar, P.S., Anderson, C.R., Ferry, C.H., Gonzalez, F.J. and Peters, J.M.. Effect of prenatal peroxisome proliferator-activated receptor-α (PPARα) agonism on postnatal development. Toxicology (2010) 276: 79-84.
  • Palkar, P.S., Borland, M.G., Naruhn, S., Ferry, C.H., Lee, C., Sk, U.H., Sharma, A.K., Amin, S., Murray, I.A., Anderson, C.R., Perdew, G.H., Gonzalez, F.J., Müller, R. and Peters, J.M.. Cellular and pharmacological selectivity of the PPARβ/δ antagonist GSK3787. Molecular Pharmacology (2010) 78: 419-430.
  • Bility, M.T., Zhu, B., Kang, B.H., Gonzalez, F.J. and Peters, J.M..  Ligand activation of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) and inhibition of cyclooxygenase 2 (COX2) enhances inhibition of skin tumorigenesis. Toxicological Sciences (2010) 113: 27-36.
  • Foreman, J.E., Sharma, A.K., Amin, S., Gonzalez, F.J. and Peters, J.M… Ligand activation of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) inhibits cell growth in a mouse mammary gland cancer cell line. Cancer Letters (2010) 288: 219-225.
  • Genovese, S., Foreman, J.E., Epifano, F., Gonzalez, F.J., Curini, M. and Peters, J.M… A natural propenoic acid derivative activates peroxisome proliferator-activated receptor-β/δ (PPARβ/δ). Life Sciences (2010) 86: 493-498.
  • Simonini, M.V., Polak, P.E., Boullerne, A.I., Peters, J.M., Richardson, J.C. and Feinstein, D.L.. Regulation of oligodendrocyte progenitor cell maturation by PPARδ: Effects on bone morphogenic proteins. ASN Neuro (2010) 2(1):art:e00025.doi:10.1042/AN20090033.
  • Foreman, J.E., Sorg, J.M., McGinnis, K.S., Rigas, B., Williams, J.L., Clapper, M.L., Gonzalez, F.J. and Peters, J.M.. Quantitative examination of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) regulation by APC/ß-catenin pathway and nonsteroidal anti-inflammatory drugs (NSAIDs). Molecular Carcinogenesis (2009) 48: 942-952.
  • Peters, J.M. and Gonzalez, F.J.. Sorting out the functional roles of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) in cell proliferation and cancer. BBA Reviews Cancer (2009) 1796: 230-241.
  • Foreman, J.E., Chang, S.C., Ehresman, D.J., Butenhoff, J.L., Anderson, C.R., Palkar, P.S., Kang, B.H., Gonzalez, F.J. and Peters J.M.. Differential hepatic effects of perfluorobutyrate (PFBA) mediated by mouse and human PPARα. Toxicological Sciences (2009) 110: 204-211.
  • Gopinathan, L., Hannon, D.B., Peters, J.M. and Vanden Heuvel, J.P. Regulation of peroxisome proliferator-activated receptor-α by MDM2.Toxicological Sciences (2009) 108: 48-58.
  • Ghosh, M., Ai, Y., Narko, K., Wang, Z., Peters, J.M. and Hla, T.. PPARδ is pro-tumorigenic in a mouse model of COX-2-induced mammary cancer. Prostaglandins and Other Lipid Mediators (2009) 88:97-100.
  • Billity, M. T., Devlin, M.K., Blazanin, N., Glick, A.B., Billin, A.N., Willson, T.M. Ward, J.M., Kang, B.H., Kennett, M.J., Gonzalez, F.J. and Peters, J.M. Ligand activation of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) inhibits chemically-induced skin tumorigenesis. Carcinogenesis (2008) 29: 2406-2414.
  • He, P., Borland, M.G., Zhu, B., Sharma, A.K., Amin, S., El-Bayoumy, K., Gonzalez, F.J. and Peters, J.M..  Effect of ligand activation of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) in human lung cancer cell lines. Toxicology (2008) 254: 112-117.
  • Girroir, E.E., Hollingshead, H.E., He, P., Zhu, B., Perdew, G.H. and Peters, J.M.. Quantitative expression patterns of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) protein in mice. Biochemical and Biophysical Research Communications (2008) 371: 456-461.
  • Borland, M.G., Foreman, J.E., Girroir, E.E., Zolfaghari, R., Sharma, A.K., Amin, S., Gonzalez, F.J., Ross, A.C. and Peters, J.M.. Ligand activation of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) inhibits cell proliferation in human HaCaT keratinocytes. Molecular Pharmacology (2008) 74: 1429-1442.
  • Shan, W. Palkar, P., Murray, I.A., McDevitt, E.I., Kennett, M.J., Kang, B.H., Isom, H.C., Perdew, G.H., Gonzalez, F.J. and Peters, J.M.. Ligand activation of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) attenuates carbon tetrachloride-induced hepatotoxicity by down-regulating pro-inflammatory gene expression. Toxicological Sciences (2008) 105: 418-428.
  • Muller, R., Komfhoff M., Peters, J.M. and Muller-Brusselbach, S.. A role for PPARβ/δ in tumor stroma and tumorigenesis. PPAR Research (2008) 534294.
  • Peters, J.M ., Hollingshead, H.E. and Gonzalez, F.J.. Role of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) in the gastrointestinal tract function and disease. Clinical Sciences (2008) 115: 107-127.
  • Hollingshead, H.E., Borland, M.G., Billin, A.N., Willson, T.M., Gonzalez, F.J. and Peters, J.M.. Ligand activation of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) and inhibition of cycoloxygenase-2 (COX2) attenuate colon carcinogenesis through independent signaling mechanisms. Carcinogenesis (2008) 29: 169-176.
  • Girroir, E.E., Hollingshead, H.E., Billin, A.N., Willson, T.M., Robertson, G.P., Sharma, A.K., Amin, S., Gonzalez, F.J. and Peters, J.M.. Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) ligands inhibit growth of UACC903 or MCF7 human cancer cell lines. Toxicology (2008) 2 43: 236-243.
  • Peters, J.M .. Mechanistic evaluation of PPAR a -mediated hepatocarcinogenesis: Are we there yet? Toxicological Sciences (2008) 101: 1-3.
  • Burdick, A. D., Bility, M.T., Girroir, E. E., Billin, A.N., Willson, T.M., Gonzalez, F.J. and Peters, J.M. Ligand activation of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) inhibits cell growth of human N/TERT-1 keratinocytes. Cellular Signaling (2007) 19: 1163-1171.
  • Hollingshead, H.E., Killins, R.L., Borland, M.G., Girroir, E.E., Billin, A.N., Willson, T.M., Sharma, A., Amin, S., Gonzalez, F.J. and Peters, J.M.. Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) ligands do not potentiate growth of human cancer cell lines. Carcinogenesis (2007) 28: 2641-2649.
  • Hollingshead, H.E., Morimura, K., Adachi, M., Kennett, M.J., Billin, A.N., Willson, T.M., Gonzalez, F.J. and Peters, J.M.. PPARβ/δ protects against experimental colitis through a ligand-independent mechanism. Digestive Diseases and Sciences (2007) 52: 2912-2919.
  • Shan, W., Nicol, C.J., Bility, M.T., Kennett, M.J., Ward, J.M., Gonzalez, F.J. and Peters, J.M.. Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) protects against chemically-induced liver toxicity in mice. Hepatology (2007) 47: 225-235.
  • Muller-Brusselbach, S., Komhoff, M., Burdick, A.D., Keil, B., Klose, K.J., Moll, R., Peters, J.M. and Muller, R.. Suppression of tumor angiogenesis and blockade of tumor growth in PPAR β-deficient mice. EMBO Journal (2007) 26: 3686-3698.
  • Ghosh, M., Wang, H., Ai, Y., Romeo, E., Luyendyk, J.P., Peters, J.M., Mackman, N., Dey, S.K. and Hla, T.. COX-2 suppresses tissue factor expression via endocannabinoid-directed PPARδ activation. The Journal of Experimental Medicine (2007) 204: 2053-2061.
  • Abdollahi, A., Schwanger, C., Kleef, J., Esposito, I., Domhan, S., Peschke, J., Hauser, K., Hahnfeldt, P., Hlatky, L., Debus, J., Peters, J.M., Freiss, H., Folkman, J. and Huber, P.E.. A transcriptional network governing the angiogenic switch: Evidence in human pancreatic carcinoma. Proceedings of the National Academy of Sciences (2007) 104: 12890-12895.
  • Guo, D., Sarkar, J., Suino-Powell, K., Xu, Y., Matsumoto, K., Jia, Y., Yu, S., Khare, S., Haldar, K., Rao, M.S., Foreman, J.E., Monga, S.P.S., Peters, J.M., Xu, H.E. and Reddy, J.K.. Induction of nuclear translocation of CAR and by PPARα synthetic ligands in mouse liver. The Journal of Biological Chemistry (2007) 282: 36766-36776.
  • Muller-Brusselbach, S., Ebrahimsade, S., Jakel, J., Eckhardt, J., Rapp, U.R., Peters, J.M., Moll, R. and Muller, R.. Growth of transgenic raf-induced lung adenomas is increased in mice with disrupted PPARβ/δ gene. International Journal of Oncology (2007) 31: 607-611.
  • Coleman, J.D., Prabhu, K.S., Thompson, J.T., Reddy, S.P., Peters, J.M., Peterson, B.R., Reddy, C.C. and Vanden Heuvel, J.P.. The oxidative stress mediator 4-hydroxynonenal is an intracellular agonist of the peroxisome proliferator-activated receptor-β/δ. Free Radical Biology and Research (2007) 42: 1155-1164.
  • Woods, C.G., Burns, A.M., Maki, A., Bradford, B.U., Cunningham, M.L., Connor. H.D., Kadiiska, M.B., Mason, R.P., Peters, J.M. and Rusyn, I.. Sustained formation of a -(4-pyridyl-1-oxide)-Ntert-butylnitrone radical adducts in mouse liver by peroxisome proliferators is dependent upon peroxisome proliferators-activated receptor-α , but not NADPH oxidase. Free Radical Biology and Medicine (2007) 42: 335-342.
  • Klaunig, J.E., Babich, M.A., Cook, J.C., David, R.M., DeLuca, J.G., McKee, R.H., Peters, J.M., Roberts, R.A. and Fenner-Crisp, P.A.. PPARα and effects of TCE. Environmental Health Perspectives (2007) 115: A2-A3.
  • Kim, D.J., Bility, M.T., Billin, A.N., Willson, T.M., Gonzalez, F.J. and Peters, J.M.. Peroxisome proliferator-activated receptor-β/δ selectively induces differentiation and inhibits cell proliferation. Cell Death and Differentiation (2006) 13: 53-60.
  • Burdick, A.D., Kim, D.J., Peraza, M.A., Gonzalez, F.J. and Peters, J.M.. The role of peroxisome proliferator-activated receptor-β/δ in epithelial cell growth and differentiation. Cellular Signaling (2006) 18: 9-22.
  • Kim, D.J., Prabhu, K.S., Gonzalez, F.J. and Peters, J.M.. Inhibition of chemically-induced skin carcinogenicity by sulindac is independent of peroxisome proliferator-activated receptor-β (PPARβ). Carcinogenesis (2006) 27: 1105-1112.
  • Marin, H.E., Peraza, M.A., Billin, A.N., Willson, T.M., Ward, J.M., Kennett, M.J., Gonzalez, F.J. and Peters, J.M.. Ligand activation of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) inhibits colon carcinogenesis. Cancer Research (2006) 66: 4394-4401.
  • Peraza, M.A., Burdick, A.D., Marin, H.E., Gonzalez, F.J. and Peters, J.M.. The toxicology of ligands for peroxisome proliferator-activated receptors (PPAR). Toxicological Sciences (2006) 90: 269-295.
  • Lee, C.H., Olson, P., Hevener, A., Mehl, I., Chong, L.W., Olefsky, J.M., Gonzalez, F.J., Ham, H., Kang, H., Peters, J.M. and Evans, R.M. PPARδ regulates glucose metabolism and insulin sensitivity. Proceedings of the National Academy of Sciences (2006) 103: 3444-3449.
  • Rusyn, I., Peters, J.M. and Cunningham, M.L.. Modes of action and species-specific effects of di-(2-ethylhexyl)phthalate in the liver. Critical Reviews in Toxicology (2006) 36: 459-479.
  • Wang, Y., Botolin, D., Xu, J., Christian, B., Jayaprakasam, B., Nair, M., Peters, J.M., Busik, J., Olson, L.K. and Jump, D.B.. Regulation of hepatic elongase and desaturase expression in diabetes and obesity. Journal of Lipid Research (2006) 47: 2028-2041.
  • Yang, Q., Yamada, A., Kimura, S., Peters, J.M. and Gonzalez, F.J.. Alterations in skin and stratified epithelia by constitutively activated PPARα . Journal of Investigative Dermatology (2006) 126: 374-385.
  • Patel, R.D., Kim, D.J., Peters, J.M. and Perdew, G.H.. The Aryl hydrocarbon receptor directly regulates expression of the potent mitogen epiregulin. Toxicological Sciences (2006) 89: 75-82.
  • Adachi, M., Kurotani, R., Morimura, K., Shah, Y., Sanford, M., Madison, B.B., Gumucio, D.L., Marin, H.E., Peters, J.M., Young, H.A. and Gonzalez, F.J.. PPARg in colonic epithelial cells protects against experimental inflammatory bowel disease. Gut (2006) 55: 1104-1113.
  • Reed, K.R., Sansom, O.J., Hayes, A.J., Gescher, A.J., Peters, J.M. and Clarke, A.R.. PPARδ status and mismatch repair mediated neoplasia in the mouse intestine. BMC Cancer (2006) 6: 113.
  • Peters, J.M. , Cheung, C. and Gonzalez, F.J.. Peroxisome proliferator-activated receptor-α (PPARα ) and liver cancer:
    Where do we stand? Journal ofMolecular Medicine (2005) 83: 774-785.
  • Kim, D.J., Murray, I., Burns, A.M., Gonzalez, F.J., Perdew, G.H. and Peters, J.M. Peroxisome proliferator-activated receptor-β (PPARβ) attenuates epidermal cell proliferation via ubiquitin-dependent down-regulation of kinase activity. The Journal of Biological Chemistry (2005) 280:9519-9527.
  • Hays, T., Rusyn, I., Burns, A.M., Gonzalez, F.J., Kennett, M.J., Ward, J.M. and Peters, J.M.. Role of the peroxisome proliferator-activated receptor-α (PPARα) in bezafibrate-induced hepatocarcinogenesis. Carcinogenesis (2005) 26:219-227.
  • Murray, I.A., Reen R.K., Leathery, N., Ramadoss, P., Bonati, L., Gonzalez, F.J., Peters, J.M., and Perdew G.H. Evidence that ligand binding is a key determinant of Ah receptor-mediated transcriptional activity. Archives of Biochemistry and Biophysics (2005) 442: 59-71.
  • Clemencet, M.C., Muzio, G., Trombetta, A., Peters, J.M., Gonzalez, F.J., Canuto, R.A. and Latruffe, N.. Differences in cell proliferation in rodent and human hepatic derived cell lines exposed to ciprofibrate. Cancer Letters (2005) 222: 217-226.
  • Duez, H., Lefebvre, B., Poulain, P., Torra, I. P., Percevault, F., Luc, G., Peters, J.M., Gonzalez, F.J., Gineste, R., Helleboid, S, Fruchart, J.C., Fievet, C., Lefebvre, B. and Staels, B.. Regulation of human apo A-I by gemfibrizil and fenofibrate via selective peroxisome proliferator-activated receptor-α modulation. Arteriosclerosis, Thrombosis, and Vascular Biology (2005) 25: 585-591.
  • Polak, P., Kalinin, S., Russo, C.D., Gavrilyuk, V., Sharp, A., Peters, J.M., Richardson, J., Willson, T.M., Weinberg, G. and Feinstein, D.L.. Protective effects of a peroxisome proliferators-activated receptor-β/δ agonist in experimental autoimmune encephalomyelitis. Journalof Neuroimmunology (2005) 168: 65-75.
  • Peters, J.M ., Kato, S. and Gonzalez, F.J. The United States-Japan workshop on: The role of nuclear receptors in carcinogenesis. Molecular Carcinogenesis (2004) 41:77-84.
  • Harman, F., Nicol, C.J., Marin, H.E., Ward, J.M., Gonzalez, F.J. and Peters. J.M. Peroxisome proliferator-activated receptor-δ/β (PPARδ/β) attenuates colon carcinogenesis. Nature Medicine (2004) 10:481-483.
  • Matsusue, K., Peters, J.M.* and Gonzalez, F.J.. Peroxisome proliferator-activated receptor-β (PPARβ) potentiates PPARg-stimulated adipogenesis. TheFASEB Journal (2004) 18:1477-1479. *Equally contributing first author.
  • Kim, D.J., Akiyama, T. E., Harman, F., Burns, A.M., Shan, W., Ward, J.M., Kennett, M.J., Gonzalez,F.J. and Peters, J.M. PPAR β(δ)-dependent regulation of ubiquitin C expression contributes to attenuation of skin carcinogenesis. The Journal of Biological Chemistry (2004) 279:23719-23727.
  • Bility, M.T., Thompson, J., McKee, R.H., David, R.M., Butala, J.H., Vanden Heuvel, J.V. and Peters, J.M.. Activation of mouse and human peroxisome proliferator-activated receptors (PPARs) by phthalate monoesters. Toxicological Sciences (2004) 82:170-182.
  • Rusyn, I., Asakura, S., Pachkowski, B., Bradford, B.U., Denissenko, M.F., Peters, J.M., Holland, S.M., Reddy, J.K., Cunningham, M.L. and Swenberg, J.A. Expression of base excision DNA repair genes is a sensitive biomarker for in vivo detection of chemical-induced chronic oxidative stress: Identification of the molecular ource of radicals responsible for DNA damage by peroxisome proliferators. Cancer Research (2004) 64:1050-1057.
  • Reed, K.R., Sansom, O.J., Hayes, A.J., Gescher, A.J., Winton, D.J., Peters, J.M. and Clarke, A.R.. PPARδ status and APC-mediated tumourigenesis in the mouse intestine. Oncogene (2004) 23:8992-8996.
  • Miyazaki , M., Dobrzyn, A., Sampath, H., Lee, S.-H., Man, W.C., Chu, K., Peters, J.M., Gonzalez, F.J. and Ntambi, J.M.. Reduced adiposity and liver steatosis by stearoyl-CoA desaturase deficiency are independent of peroxisome proliferator-activated receptor-α. The Journal of Biological Chemistry (2004) 279:35017-35024.
  • Akiyama, T.E., Lambert, G., Nicol, C.J., Matsusue, K., Peters, J.M., Brewer Jr., H.B. and Gonzalez, F.J.. Peroxisome proliferator-activated receptor-β/δ regulates very low density lipoprotein production and catabolism in mice on a western diet. The Journal of Biological Chemistry (2004) 279:20874-20881.
  • Nicol, C.J., Yoon, M., Ward, J.M., Yamashida, M., Fukamachi, K., Peters, J.M. and Gonzalez, F.J.. PPARγ deficiency increases susceptibility to DMBA-induced mammary and skin carcinogenesis. Carcinogenesis (2004) 25:1747-1755.
  • Nakajima, T., Kamijo, Y., Tanaka, N., Fukushima, Y., Tanaka, E., Kiyosawa, K., Peters, J.M., Gonzalez, F.J. and Aoyama, T. Peroxisome proliferator-activated receptor-α (PPAR-α) protects against alcohol-induced liver damage. Hepatology (2004)40:972-980.
  • Peters, J.M., Aoyama, T., Burns, A.M. and Gonzalez, F.J.. Bezafibrate is a dual ligand for PPARα and PPARβ: Studies using null mice. Biochimica Biophysica Acta-Molecular and Cell Biology of Lipids (2003) 1632:80-89.
  • Tien, E.S., Gray, J.P., Peters, J.M. and Vanden Heuvel, J.P.. Comprehensive gene expression analysis of peroxisome proliferator-treated immortalized hepatocytes from the PPARα-null mouse. Cancer Research (2003) 63:5767-5780.
  • Klaunig, J.E., Babich, M.A., Baetcke, K.P., Cook, J.C., Corton, J.C., David, R.M., DeLuca, J.G., Lai, D.Y., McKee, R.H., Peters, J.M., Roberts, R.A. and Fenner-Crisp, P.A.. PPARα agonist-induced rodent tumors: Mode(s) of action and human relevance. Critical Reviews in Toxicology (2003) 33:655-780.
  • Rosenberger, T.A., Hovda, J.T. and Peters, J.M.. Targeted disruption of peroxisomal proliferator-activated receptor β(δ) results in distinct gender differences in mouse brain phospholipid and esterified FA levels. Lipids (2002) 37:495-500.
  • Rao, M.S., Peters, J.M., Gonzalez, F.J. and Reddy, J.K.. Hepatic regeneration in peroxisome proliferator-activated receptor-α-null mice after partial hepatectomy. Hepatology Research (2002) 22:52-57.
  • Ripp, S.L., Fitzpatrick, J.L., Peters, J.M. and Prough, R.A.. Induction of CYP3A Expression by DHEA: Involvement of the Pregnane X Receptor. Drug Metabolism and Disposition (2002) 30:570-575.
  • Ntambi, J.M., Choi, Y., Park, Y., Peters, J.M. and Pariza, M.W.. Effects of conjugated linoleic acid (CLA) on immune responses, body composition and stearoyl-CoA desaturase. Canadian Journal of Applied Physiology (2002) 27:617-627.
  • Reynolds, K., Novosad. B., Hoffhines, A., Gipson, J., Johnson, J., Peters, J., Gonzalez, F., Gimble, J. and Hill, M.. Pretreatment with troglitazone decreases lethality during endotoxemia in mice. Journal of Endotoxin Research (2002) 8:307-314.
  • Akiyama, T., Nicol, C.J., Fievet, C., Staels, B., Ward, J.M., Gonzalez, F.J., Auwerx, J. and Peters, J.M.. Peroxisome proliferator-activated receptor-α (PPARα) regulates lipid homeostasis but is not associated with obesity: Studies with congenic mouse lines. The Journal of Biological Chemistry (2001) 276:39088-39093.
  • Kiss, A., Ortiz-Aguayo, R., Sharp, R., Merlino, G., Thorgeirsson, S.S., Gonzalez, F.J. and Peters, J.M.. Evidence that reduction of hepatocyte growth factor (HGF) is not required for peroxisome proliferator-induced hepatocyte proliferation. Carcinogenesis (2001) 22:975-979.
  • Vanden Heuvel, J.P. and Peters, J.M.. Biology of the PPAR family of receptors. Comments on Toxicology (2001) 7: 233-258.
  • Peters, J.M ., Park, Y., Gonzalez, F.J. and Pariza, M.W.. Influence of conjugated linoleic acid (CLA) in peroxisome proliferator-activated receptor-α (PPARα)-null mice. Biochimica Biophysica Acta -Molecular and Cell Biology of Lipids (2001) 1533:233-242.
  • Wu, P., Peters, J.M. and Harris, R.A.. Adaptive increase in pyruvate dehydrogenase kinase 4 during starvation is mediated by peroxisome proliferator-activated receptor-α. Biochemical and Biophysical Research Communications (2001) 287:391-396.
  • Dallongeville, J., Bauge, E., Tailleux, A., Peters, J.M., Gonzalez, F.J. and Staels, B.. Peroxisome proliferator-activated receptor-α is not rate limiting for lipoprotein-lowering action of fish oil. The Journal of Biological Chemistry (2001) 276:4634-4639.
  • Crabb, D.W., Pinaire, J., Chou, W., Sissom, S., Peters, J.M., Harris, R.A. and Stewart, M.. Peroxisome proliferator-activated receptors (PPAR) and the mitochondrial aldehyde dehydrogenase (ALDH2) promoter in vitro and in vivo. Alcoholism: Clinical and Experimental Research (2001) 25:945-952.
  • Guerre-Millo, M., Rouault, C., Poulain, P., Andre, J., Poitout, V., Peters, J.M., Gonzalez, F.J., Fruchart, J.-C., Reach, G. and Staels, B.. PPARα-null mice are protected from high-fat diet-induced insulin resistance. Diabetes (2001) 50:2809-2814.
  • Cui, X., Kawashima, H., Barclay, T.B., Peters, J.M., Gonzalez, F.J., Morgan, E.T. and Strobel, H.W.. Molecular cloning and regulation of expression of two novel mouse CYP4F genes. Journal of Pharmacology and Experimental Therapeutics (2001) 296:542-550.
  • Xu, S., Zhu, B.T., Turan, V., Rusyn, I., Thurman, R., Peters, J.M., Gonzalez, F.J. and Conney, A.H.. Peroxisome proliferator-activated receptor alpha (PPARα)-dependent induction of liver microsomal esterification of estradiol and testosterone by a prototypical peroxisome proliferator. Endocrinology (2001) 142:3554-3557.
  • Michalik, L., Desvergne, B., Tan. N.S., Basu-Modak, S., Escher, P., Rieusset, J., Peters, J.M., Kaya, G., Gonzalez, F.J., Zakany, J., Metzger, D., Chambon, P., Duboule, D. and Wahli, W.. Impaired skin wound healing in PPARα and PPARβ mutant mice. Journal of Cell Biology (2001) 154:799-814.
  • Rusyn, I., Kadiiska, M.B., Dikalova, A., Kono, H., Yin, M., Tsuchiya, K., Mason, R.P., Peters, J.M., Gonzalez, F.J., Segal, B.H., Holland, S.M. and Thurman, R.G.. Phthalates rapidly increase production of reactive oxygen species in vivo: Role of Kupffer cells. Molecular Pharmacology (2001) 59:744-750.
  • Wheeler, M.D., Kono, H., Yin, M., Nakagami, M., Uesugi, T., Arteel, G.E., Gabele, E., Rusyn, I., Yamashina, S., Froh, M., Adachi, Y., Iimuro, Y., Bradford, B.U., Smutney, O.M., Connor, H.D., Mason, R.P., Goyert, S.M., Peters, J.M., Gonzalez, F.J., Samulski, R.J. and Thurman, R.G.. The role of Kupffer cell oxidant production in early ethanol-induced liver injury. Free Radical Biology and Medicine (2001) 31:1544-1549.
  • Peters, J.M ., Lee, S.S.T., Li, W., Ward, J.M., Gavrilova, O., Everett, C., Reitman, M.L., Hudson, L.D. and Gonzalez, F.J.. Growth, adipose, brain and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor β(δ). Molecular and Cellular Biology (2000) 20:5119-5128.
  • Peters, J.M ., Rusyn, I., Rose, M.L., Gonzalez, F.J. and Thurman, R.G.. Peroxisome proliferator-activated receptor a is restricted to hepatic parenchymal cells, not Kupffer cells: Implications for the mechanism of action of peroxisome proliferators in hepatocarcinogenesis. Carcinogenesis (2000) 21:823-826.
  • Peters, J.M. Roles of the peroxisome proliferator-activated receptors in development. Frontiers in Fetal Health: A Global Perspective (2000) 2:13-15.
  • Sapone, A., Peters, J.M., Sakai, S., Tomita, S., Papiha, S.S., Dai, R., Friedman, F.K. and Gonzalez, F.J.. The human peroxisome proliferator-activated receptor-α gene: Identification and functional characterization of two natural allelic variants. Pharmacogenetics (2000) 10:321-334.
  • Turunen, M., Peters, J.M., Gonzalez, F.J., Schedin, S. and Dallner, G.. Influence of peroxisome proliferator-activated receptor-α on ubiquinone biosynthesis. Journal of Molecular Biology (2000) 297:607-614.
  • Wu, X., Peters, J.M., Gonzalez, F.J., Prasad, H.S., Rohrer, M.D. and Gimble, J.M.. Frequency of stromal lineage colony forming units in the bone marrow of peroxisome proliferator-activated receptor-α null mice. Bone (2000) 26:21-26.
  • Portilla, D., Dai, G., Peters, J.M., Gonzalez, F.J., Crew, M.D. and Proia, A.D.. Etomoxir-induced PPAR-α-modulated enzymes protect during renal failure. American Journal of Physiology (2000) 278:F667-675.
  • Hunt, M.C., Lindquist, P.J.G., Peters, J.M., Gonzalez, F.J., Diezfalusy, U. and Alexson, S.E.H.. Involvement of the peroxisome proliferator-activated receptor-α in regulating long-chain acyl-CoA thioesterases. Journal of Lipid Research (2000) 41:814-823.
  • Pan, D.A., Mater, M.K., Thelen, A.P., Peters, J.M., Gonzalez, F.J. and Jump, D.B.. Evidence against the PPARα as the mediator for PUFA suppression of hepatic L-pyruvate kinase gene expression. Journal of Lipid Research (2000) 41:742-751.
  • Hasmall , S.C., James, N.H., Macdonald, N., Gonzalez, F.J., Peters, J.M. and Roberts, R.A.. Suppression of mouse hepatocyte apoptosis by peroxisome proliferators: Role of PPARα and TNFα . Mutation Research (2000) 448:193-200.
  • Holden, P.R., Hasmall, S.C., James, N.H., West, D.R., Brindle, R.D., Gonzalez, F.J., Peters, J.M. and Roberts, R.A.. Tumour necrosis factor-α (TNFα): Role in suppression of apoptosis by the peroxisome proliferator nafenopin. Cellular and Molecular Biology (2000) 46:29-39.
  • DeLuca, J.G., Doebber, T.W., Kelly, L.J., Kemp, R.E., Molon-Noblot, S., Sahoo, S.P., Ventre, J., Wu, M.S., Peters, J.M., Gonzalez, F.J. and Moller, D.E.. Evidence for PPARα-Independent Peroxisome Profliferation: Effects of PPARg/δ -Specific Agonists in PPAR a Null Mice. Molecular Pharmacology (2000) 58:470-476.
  • Peters, J.M, Narotsky, M.G., Elizondo, G., Fernandez-Salguero, P.M., Gonzalez, F.J. and Abbott, B.D.. Amelioration of TCDD-induced teratogenesis in aryl hydrocarbon receptor (AHR)-null mice. Toxicological Sciences (1999) 47:86-92.
  • Peters, J.M ., Morishima, H., Ward, J.M., Coakley, C.J., Kimura, S. and Gonzalez, F.J.. Role of CYP1A2 in the toxicity and carcinogenicity of long-term phenacetin feeding. Toxicological Sciences (1999) 50:82-89.
  • Barclay, T.B., Peters, J.M., Sewer, M.B., Ferrari, L., Gonzalez, F.J. and Morgan, E.T.. Modulation of cytochrome P-450 gene expression in endotoxemic mice is tissue specific and peroxisome proliferator-activated receptor-α-dependent. Journal of Pharmacology and Experimental Therapeutics (1999) 290:1250-1257.
  • Kersten, S., Seydoux, J., Peters, J.M., Gonzalez, F.J., Desvergne, B. and Wahli, W.. Peroxisome proliferator-activated receptor a mediates the adaptive response to fasting. The Journal of Clinical Investigations (1999) 103:1489-1498.
  • Constan, A.A., Sprankle, C.S., Peters, J.M., Kedderis, G.L., Everitt, J.I., Wong, B.A., Gonzalez, F.J. and Butterworth, B.E.. Metabolism of chloroform by cytochrome P450 2E1 is required for induction of toxicity in the liver, kidney and nose of male mice. Toxicology and Applied Pharmacology (1999) 160:120-126.
  • Guidotti, L.G., Eggers, C.M., Raney, A.K., Chi, S.Y., Peters, J.M., Gonzalez, F.J. and McLachlan, A.. In vivo regulation of hepatitis B virus replication by peroxisome proliferators. The Journal of Virology (1999) 73:10377-10386.
  • Hashimoto, T., Fujita, T., Usuda, N., Cook, W., Qi, C., Peters, J.M., Gonzalez, F.J., Yeldandi, A.V., Rao, M.S. and Reddy, J.K.. Peroxisomal and mitochondrial fatty acid β-oxidation in mice nullizygous for both PPAR a and fatty acyl CoA oxidase: Genotype correlation with fatty liver phenotype.The Journal of Biological Chemistry (1999) 274:19228-19236.
  • Delerive, P., De Bosscher, K., Besnard, S., Vanden Berghe, W., Peters, J.M., Gonzalez, F.J., Fruchart, J.-C., Tedgui, A., Haegeman, G. and Staels, B.. Peroxisome proliferator-activated receptor-α negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kB and AP-1. The Journal of Biological Chemistry (1999) 274:32048-32054.
  • Hill, M.R., Clarke, S., Rodgers, K., Hoebing, B., Peters, J.M., Gonzalez, F.J. and Gimble, J.M.. Effect of peroxisome proliferator-activated receptor alpha activators on tumor necrosis factor expression in mice during endotoxemia. Infection and Immunity (1999) 67:3488-3493.
  • Kockx, M., Gervois, P.P., Poulain, P., Derudas, B., Peters, J.M., Gonzalez, F.J., Prineen, H.M.G. and Staels, B.. Fibrates suppress fibrinogen gene expression in rodents via activation of the peroxisome proliferator-activated receptor. Blood (1999) 93:2991-2998.
  • Kono, H., Bradford, B.U., Yin, M., Sulik, K.K., Koop, D.R., Peters, J.M., Gonzalez, F.J., McDonald, T., Nikolova, A., Kadiiska, M., Mason, R.P. and Thurman, R.G.. CYP2E1 is not involved in early alcohol-induced liver injury. American Journal of Physiology (1999) 277:G1259-G1267.
  • Peters, J.M ., Aoyama, T., Cattley, R.C., Usuda, N., Hashimoto, T. and Gonzalez, F.J.. The role of peroxisome proliferator-activated receptor-α in altered cell cycle regulation in mouse liver. Carcinogenesis (1998) 19:1989-1994.
  • Aoyama, T., Peters, J.M., Iritani, N., Nasu-Nakajima, T., Furihata, K., Hashimoto, T. and Gonzalez, F.J.. Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor-α (PPARα) The Journal of Biological Chemistry (1998) 273:5678-5684.
  • Gonzalez, F.J., Peters, J.M. and Cattley, R.C.. Mechanism of action of the non-genotoxic peroxisome proliferators: Role of the peroxisome proliferator-activated receptor-α (PPARα). The Journal of the National Cancer Institute (1998) 90: 1702-1709.
  • Ward, J.M., Peters, J.M., Perella, C.M. and Gonzalez, F.J.. Receptor and non-receptor-mediated organ-specific toxicity of di(2-ethylhexyl) phthalate (DEHP) in peroxisome proliferator-activated receptor-α-null mice. Toxicologic Pathology (1998) 26:240-246.
  • Motojima, K., Passilly, P., Peters, J.M., Gonzalez, F.J. and Latruffe, N.. Expression of putative fatty acid transporter genes are regulated by PPARα and γ activators in a tissue- and inducer-specific manner. The Journal of Biological Chemistry (1998) 273:16710-16714.
  • Peters, J.M. , Hennuyer, N., Staels, B., Fruchart, J.-C., Fievet, C., Gonzalez, F.J. and Auwerx, J.. Alterations in lipoprotein metabolism in PPARα deficient mice. The Journal of Biological Chemistry (1997) 272:27307-27312.
  • Peters, J.M. , Cattley, R.C. and Gonzalez, F.J.. Role of PPARα in the mechanism of action of the non-genotoxic carcinogen and peroxisome proliferator Wy 14,643. Carcinogenesis (1997) 18:2029-2033.
  • Peters, J.M ., Taubeneck, M.W., Keen, C.L. and Gonzalez, F.J.. Di(2-ethylhexyl) phthalate induces a functional zinc deficiency and teratogenesis during pregnancy independent of peroxisome proliferator-activated receptor-α . Teratology (1997) 56:311-316.
  • Ren, B., Thelen, A.P., Peters, J.M., Gonzalez, F.J. and Jump, D.B.. Polyunsaturated fatty acid suppression of hepatic S14 gene transcription does not require PPARα . The Journal of Biological Chemistry (1997) 272:26827-26832.
  • Motojima, K., Peters, J.M. and Gonzalez, F.J.. PPAR a mediates peroxisome proliferator-induced transcriptional repression of non-peroxisomal gene expression in the mouse. Biochemical Biophysical Research Communications (1997) 230:155-158.
  • Hanna, L., Peters, J.M., Wiley, L.M., Clegg, M.S. and Keen, C.L.. Comparative effects of essential and nonessential metals on preimplantation mouse embryo development in vitro. Toxicology (1997) 116:123-131.
  • Hanna, L.A., Peters, J.M., Wiley, L.M., Zidenberg-Cherr, S.C. and Keen, C.L. An enhancing effect of maternal zinc deficiency and 137Cs g -irradiation on the frequency of fetal malformations in mice. Teratogenesis, Carcinogenesis and Mutagenesis (1997) 17:127-137.
  • Devchand, P.R., *Keller, H., * Peters, J.M., Vazquez, M., Gonzalez, F.J. and Wahli, W. The PPARα-leukotriene pathway to inflammation control. Nature (1996) 384: 34-43. (*equally contributing second author)
  • Peters, J.M. , Zhou, Y.C., Ram, P.A., Lee, S.S.T., Gonzalez, F.J. and Waxman, D.J.. Peroxisome proliferator-activated receptor-α (PPAR-α) mediates gene induction by dehydroepiandrosterone 3 b -sulfate. Molecular Pharmacology (1996) 50:67-74.
  • Peters, J.M., Tsark, E.C. and Wiley, L.M.. Radiosensitive target in the mouse embryo chimera assay: Implications that the target involves autocrine growth factor function. Radiation Research (1996) 145: 722-729.
  • Peters, J.M. and Wiley, L.M.. Evidence that murine preimplantation embryos expressaryl hydrocarbon receptor. Toxicology and Applied Pharmacology (1995) 134: 214-221.
  • Peters, J.M. , Wiley, L.M., Zidenberg-Cherr, S.C. and Keen, C.L. Periconceptional zinc deficiency affects uterine 3H-estradiol binding in mice. Teratogenesis, Carcinogenesis and Mutagenesis (1995) 15:23-31.
  • Peters, J.M. , Duncan, J.R., Wiley, L.M. and Keen, C.L.. Influence of antioxidants on cadmium toxicity of mouse preimplantation embryos in vitro. Toxicology (1995) 99:11-18.
  • Peters, J.M. , Duncan, J.R., Rucker, R.B., Wiley, L.M. and Keen, C.L.. Effect of a metallothionein antisense oligonucleotide on embryo development. Reproductive Toxicology (1995) 9:123-130.
  • Peters, J.M. , Wiley, L.M., Zidenberg-Cherr, S.C. and Keen, C.L. Influence of periconceptional zinc deficiency on embryonic plasma membrane function in mice. Teratogenesis, Carcinogenesis and Mutagenesis (1993) 13:15-21.
  • Peters, J.M. The influence of zinc during early embryonic development. Ph.D. Dissertation (1992).
  • Peters, J.M. , Wiley, L.M., Zidenberg-Cherr, S.C. and Keen, C.L. The influence of short-term maternal zinc deficiency on the in vitro development of preimplantation mouse embryos. Proceedings of the Society for Experimental Biology and Medicine (1991) 198:561-568.
  • Keen, C. L., Peters, J. M. and Hurley, L. S. The effect of valproic acid on 65Zn distribution in the pregnant rat. Journal of Nutrition (1989) 119:607-611.
  • Peters, J.M. , Lonnerdal, B. and Keen, C. L. Effect of the antihypertensive drug hydralazine on mineral metabolism in the rat. Toxicology Letters (1988) 41:193-202.
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