Proper folding and appropriate function of the cellular proteome is essential for life. However, this process is constant challenged by stresses that dynamically alter the cellular folding environment. The Zhang lab aims to 1) develop chemical tools to monitor cellular stresses that influence protein folding in real time; 2) decipher how the energy landscapes associated with proper protein folding and function are regulated by the cellular folding environment; and 3) examine how this regulation leads to significant biological consequences. The success of this research program not only discerns the origin and consequence of the biological regulation of protein folding and function in a fashion that has not been considered to date, but also potentiates diagnosis and therapeutic strategies to human diseases that are rooted in defective protein folding and function.
Before joining the faculty at Penn State, Zhang was a postdoctoral scholar at the Scripps Research Institute. He earned a Ph.D. at the California Institute of Technology in 2010, a M.S. at the Dalian Institute of Chemical Physics, Chinese Academy of Sciences in 2004, and completed an undergraduate degree at the University of Science and Technology of China in 2001. Zhang’s awards and honors include a Burroughs Wellcome Fund Career Award at the Scientific Interface, a Helen Hay Whitney Postdoctoral Fellowship, an ACS Nobel Laureate Signature Award for Graduate Education in Chemistry, and a Caltech Herbert Newby McCoy Award in Chemistry.