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Signal transduction and antibiotic induced stress responses in bacteria.
Regulation of gene expression by RNA structure and RNA-binding proteins
Single cell / single molecule study of chromatin and gene regulation
Structural biology of metalloproteins
Mechanisms of metalloenzymes and metallofactor assembly
Mechanisms of cofactor action in enymatic reactions
Physiology, biochemistry, genetics, and genomics of photosynthetic bacteria
RNA polymerases and RNA-binding proteins in viral infection and mitochondrial disease
Multidisciplinary field of biological surface
and interface science
Molecular approaches to the unique biology of JC virus
Transcriptional regulation of the hsp70 heat shock gene in Drosophila
Genetics of neurodevelopmental disorders
Mechanism of cellulose biosynthesis in arabidopsis
Molecular Genetics of Metabolism and Development in C. elegans
Genomics and gene regulation
Biochemical and molecular bases of self/non-self recognition during plant reproduction
Protein quality control and new antibiotics.
Structural biology of RNA and RNA-protein complexes
Bioinorganic chemistry- spectroscopic and kinetic studies on the mechanisms of iron-containing enzymes
Growth control and cancer genetics
Protein structure, function and evolution
Molecular parasitology and structural biology of malaria (Plasmodium spp.)
Understanding the molecular mechanisms of gene regulation and metabolism in the malaria parasite Plasmodium falciparum using functional genomics and metabolomics
Understanding of the role and function
of GABAergic transmission in health and disease
Computational biology and regulatory genomics.
Materials chemistry: surface chemistry,
layered materials, self-assembly, artificial photosynthesis, catalysis,
Breast cancer and immune system
Our research focuses on the bacterial cell envelope, and in particular on lipid metabolism, across a set of key human pathogens including Staphylococcus aureus and Pseudomonas aeruginosa.
Bacterial gene expression within natural host environments; Host-microbe symbioses
Structural and Mechanistic Enzymology of Prokaryotic RNA Polymerases
Comparative genome analysis
1. Functional bases of signal transduction and gene regulation by AAA+ATPases in bacteria.
2. Degradation of lignocellulose by cellulases.
3. Synthesis of cellulose.
Signal transduction and iron transport in bacteria as a target for novel antibiotic development
Biochemistry and genomics and eukaryotic transcription regulation
Chromatin structure and gene expression, DNA damage resistance pathways
Bioinformatics, Computational Genomics, Pharmacogenomics, Genetic Architecture of Complex Human Traits
Subcellular compartmentalization of neurons
Small GTPase regulation of epithelial cell motility
Regulation of growth factor signaling, proteogylcan modulation of morphogen function, nervous system assembly and synapse development
Analytical, Biological, Computational/Theoretical, Physical, Biomedical
Neurovirology, genomics of pathogen variation, neuron-virus relationships
Structural biology of eukaryotic gene regulation
Roles of the cytoskeleton in Drosophila development: molecular and genetic approaches
Characterization and biochemical analysis of cellulose synthesis in a variety of organisms.
Mechanism and regulation of fungal degradation of lignin.
Dissimilatory Iron reduction
Epigenetic histone modifications in cell differentiation and cancer
Research interests focus on biological chemistry and chemical biology.
Department of Biochemistry & Molecular Biology, 107 Althouse Lab, University Park, PA 16802
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