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Zachary Gerhart-Hines

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Zachary Gerhart-HinesI graduated from the Pennsylvania State University and the Schreyer Honors College in 2004 with a B.S. in Biochemistry and Molecular Biology (BMB).  I carried out my graduate work in the lab of Dr. Pere Puigserver at the Johns Hopkins University School of Medicine where I received my Ph.D. in Biochemistry, Cellular and Molecular Biology in 2011. I'm currently a postdoctoral fellow in the lab of Dr. Mitchell Lazar at the University of Pennsylvania School of Medicine's Institute for Diabetes, Obesity, and Metabolism.

I'm indebted to Penn State for the classroom education and laboratory experience I received from the Eberly College of Science. The wide array of topics addressed within the BMB curriculum established a solid base from which I was able to develop as a scientist. However, the distinguishing advantage of Penn State for me was the opportunity to work directly with faculty members who are committed to training and preparing the next generation of scientists.

I conducted my undergraduate thesis research in the lab of Dr. Joseph Reese, studying the transcriptional control of DNA damage repair pathways. As a result of Dr. Reese's mentorship, I developed invaluable research skills, such as experimental design and problem-solving techniques, which cannot be adequately acquired through structured coursework alone. Moreover, I still look to Dr. Reese for continued advice and support in career decisions. The education I received from the BMB department and the Eberly College of Science at Penn State fostered my creativity and independence as a researcher and provided me with the tools necessary to successfully troubleshoot any of the challenges I've faced.

Publications:

Dominy JE, Jr., Lee Y, Gerhart-Hines Z. Puigserver P (2010) Nutrient-dependent regulation of PGC-1 alpha's acetylation state and metabolic function through the enzymatic activities of Sirt1/GCN5. Biochem Biophys Acta, 1804: 1676-1683.

Suchankova G, Nelson LE, Gerhart-Hines Z, Kelly M, Gauthier MS, Saha AK, Ido Y, Puigserver P, Ruderman NB (2009) Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells. Biochem Biophys Res Commun, 378:836-841.

Schafer ZT, Graaaian AR, Song L, Jiang Z, Gerhart-Hines Z, Irie HY, Gao S, Puigserver P, Brugge JS (2009) Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment. Nature, 461: 109-113.

Canto C, Gerhart-Hines Z, Feige JN, Lagouge M, Noriega L. Milne JC, Elliott PJ, Puigserver P, Auwerx J (2009) AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature, 458: 1056-1060.

Rodgers JT, Lerin C, Gerhart-Hines Z, Puigserver P (2008) Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways. FEBS Lett. 582: 46-53.

Gerhart-Hines Z, Rodgers JT, Bare O, Lerin C, Kim SH, Mostoslavsky R, Alt FW, Wu Z, Puigserver P (2007) Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J, 26: 1913-1923.

Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott P, Geny B, Laakso M, Puigserer P, Auwerx J (2006) Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1 alpha. Cell, 127: 1109-1122.

Submitted Publications:

Gerhart-Hines Z, Dominy JE, Jr., Bl├Ąttler SM, Jedrychowski MP, Banks AS, Gygi SP, Puigserver P (2011) cAMP/PKA rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD+. (Molecular Cell, under review).

Carracedo A, Weiss D, Leliaert A, Bhasin M, De Boer V, Laurent G, Song SJ, Ito K, Finley LS, Libermann T, Gerhart-Hines Z, Puigserver P, Haigis MC, Richardson AL, Schafer ZT, and Pandolfi PP (2011) Regulation of fatty acid oxidation by PML redefines its role in tumorigenesis. (Nature Medicine, under review).