Biochemistry and Molecular Biology
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Craig Cameron

Craig Cameron

Main Content

  • Professor of Biochemistry and Molecular Biology
  • Eberly Chair in Biochemistry and Molecular Biology
201 Althouse Laboratory
University Park, PA 16802
Phone: (814) 863-8705

Research Interests

RNA polymerases and RNA-binding proteins in viral infection and mitochondrial disease

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CV for Dr. Craig Cameron

Graduate Programs


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Research Summary


RNA Polymerases and RNA-binding Proteins in Viral Infection and Mitochondrial Disease

Since its inception, the primary goal of this laboratory has been development of strategies to treat or to prevent infections by RNA viruses.  We have used poliovirus and hepatitis C virus (HCV) as our primary model systems.  Our expertise in virology, biochemistry and mechanistic enzymology brings a unique combination of intellectual and technical resources to the study of RNA viruses.  Our initial focus was the viral RNA-dependent RNA polymerase (RdRp).  In particular, we were interested in the kinetic, thermodynamic and structural basis for fidelity of nucleotide incorporation, a topic of considerable importance not only for accurate maintenance, transmission and expression of genetically encoded information but also for targeting the RdRp for antiviral therapy.  These studies have led to exciting discoveries that have moved the lab into many new areas, including enzyme dynamics, vesicular trafficking, innate immunity, vaccine development and mitochondrial molecular biology.  Our work is highly collaborative and includes research teams from academia (local, national and international), government and industry.  We currently have projects in the following areas:  RNA-dependent RNA polymerase mechanism, Picornavirus genome replication, Flavivirus genome replication, Enzymology of the flavivirus replicase, and Mitochondrial transcription and disease.


Craig Cameron

Selected Publications

Journal Articles


  • Woodman, A., Arnold, J. J., Cameron, C. E., and Evans, D. J. (2016). Biochemical and genetic analysis of the role of the viral polymerase in enterovirus recombination. Nucleic Acids Res 44, 6883-95.
  • Oran AR, Adams CM, Zhang XY, Gennaro VJ, Pfeiffer HK, Mellert HS, Seidel HE, Mascioli K, Kaplan J, Gaballa MR, Shen C, Rigoutsos I, King MP, Cotney JL, Arnold JJ, Sharma SD, Martinez-Outschoorn UE, Vakoc CR, Chodosh LA, Thompson JE, Bradner JE, Cameron CE, Shadel GS, Eischen CM, McMahon SB. (2016). Multi-focal control of mitochondrial gene expression by oncogenic MYC provides potential therapeutic targets in cancer. Oncotarget. 7, 72395-72414.
  • Baumgart BR, Wang F, Kwagh J, Storck C, Euler C, Fuller M, Simic D, Sharma S, Arnold JJ, Cameron CE, Van Vleet TR, Flint O, Bunch RT, Davies MH, Graziano MJ, Sanderson TP. (2016). Effects of BMS-986094, a Guanosine Nucleotide Analogue, on Mitochondrial DNA Synthesis and Function Toxicological sciences 15, 396-408.
  • Griesemer SB, Kramer LD, Van Slyke GA, Pata JD, Gohara DD, Cameron CE, Ciota AT. (2016). Mutagen resistance and mutation restriction of St. Louis encephalitis virus. J Gen Virol. Dec 12. [Epub ahead of print]
  • Yang, X., Liu, X., Musser, D. M., Moustafa, I. M., Arnold, J. J., Cameron, C. E., and Boehr, D. D. (2017). Triphosphate Reorientation of the Incoming Nucleotide as a Fidelity Checkpoint in Viral RNA-dependent RNA Polymerases. J Biol Chem 292, 3810-3826.
  • Uchida, A., Murugesapillai, D., Kastner, M., Wang, Y., Lodeiro, M. F., Prabhakar, S., Oliver, G. V., Arnold, J. J., Maher, L. J., Williams, M. C., and Cameron, C. E. (2017). Unexpected sequences and structures of mtDNA required for efficient transcription from the first heavy-strand promoter. eLife 6
  • Shengjuler, D., Sun, S., Cremer, P. S., and Cameron, C. E. (2017). PIP-on-a-chip: A Label-free Study of Protein-phosphoinositide Interactions.JoVE
  • Murugesapillai, D., Bouaziz, S., Maher, L. J., Israeloff, N. E., Cameron, C. E., and Williams, M. C. (2017). Accurate nanoscale flexibility measurement of DNA and DNA-protein complexes by atomic force microscopy in liquid. Nanoscale 9, 11327-11337.
  • Huang, P. N., Jheng, J. R., Arnold, J. J., Wang, J. R., Cameron, C. E., and Shih, S. R. (2017). UGGT1 enhances enterovirus 71 pathogenicity by promoting viral RNA synthesis and viral replication. PLoS Pathogens 13, e1006375.
  • Dulin, D., Arnold, J. J., van Laar, T., Oh, H. S., Lee, C., Perkins, A. L., Harki, D. A., Depken, M., Cameron, C. E., and Dekker, N. H. (2017). Signatures of Nucleotide Analog Incorporation by an RNA-Dependent RNA Polymerase Revealed Using High-Throughput Magnetic Tweezers. Cell Reports 21, 1063-1076.
  • Guo, F., Li, S., Caglar, M. U., Mao, Z., Liu, W., Woodman, A., Arnold, J. J., Wilke, C. O., Huang, T. J., and Cameron, C. E. (2017). Single-Cell Virology: On-Chip Investigation of Viral Infection Dynamics. Cell Reports 21, 1692-1704.
  • Guo, L., Sharma, S. D., Debes, J., Beisang, D., Rattenbacher, B., Louis, I. V., Wiesner, D. L., Cameron, C. E., and Bohjanen, P. R. (2018). Nucleic Acids Res. 2018 Jan 29 [Epub ahead of print]



Review Articles

  • Cameron, C. E. (2013). Future virology: A mitochondriac's perspective. Future Virol. 8, 933-935.
  • Cameron, C. E., Moustafa, I.M. and Arnold, J.J. (2016). Fidelity of nucleotide incorporation by the RNA-dependent RNA polymerase from poliovirus. Enzymes 39, 293-323.


Books and Edited Volumes

  • Cameron, C. E., Götte, M., and Raney K.D. (2009). Viral Genome Replication. Springer Publishers, NY.
  • Cameron, C. E. and Cline S.D. (2012). Mitochondrial Gene Expression. Biochimica et Biophysica Acta (BBA)- Gene Regulatory Mechanisms. Volume 1819, Issues 9-10, 913-1112.