Biochemistry and Molecular Biology
Penn State Science
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Shawn Xiong

Shawn Xiong

Main Content

  • Assistant Teaching Professor
123 South Frear Laboratory
University Park, PA 16802
Phone: (814) 865-4825

Research Interests

  • Understanding the mechanisms of Eukaryotic signaling through structural biology.
  • Storytelling Socioscientific issues in Higher Education.
  • Course based Undergraduate Research Experiences (CURE) in Biochemistry


  • PhD: Biochemistry, University of Toronto (Distinction)
  • BSc: Chemistry-Microbiology, University of Manitoba (Honors)

Selected Publications

  • A feed forward loop enforces Yap/TAZ signaling during tumorigenesis. Gill M, Zhang Y, Gregorieff A, Zhang L, Narimatsu M, Song S, Xiong S, Christova T, Couzens AL, Zlotta AR, van der Kwast TH, Gingras AC, Sicheri F, Wrana JL, Attisano L. Nature Commun. (2018 accepted)
  • Structural basis for auto-inhibition of the NDR1 kinase domain by an atypically long activation segment. Xiong S, Lorenzen K, Couzens, AL, Templeton CM, Rajendran D, Mao DYL, Huang YC, Chiovitti D, Kurinov I, Guettler S, Gingras AC, Sicheri F. Structure. (2018 June)
  • MOB1 mediated phosphor-recognition in the core mammalian Hippo pathway. Xiong S, Couzens AL, Knight JDR, Mao DY, Guettler S, Picaud S, Kurinov I, Filippakopoulos P, Sicheri F, Gingras AC. Mol Cell Proteomics. (2017 Jun)
  • Regulation of protein interactions by Mps One Binder (MOB1) phosphorylation. Xiong S, Couzens AL, Kean MJ, Mao DY, Guettler S, Kurinov I, Gingras AC, Sicheri F. Mol Cell Proteomics. (2017 June)
  • Determination of a molecular shape for netrin-4 from hydrodynamic and small angle X-ray scattering measurement. Patel TR, Reuten R, Xiong S, Meier M, Winzor DJ, Kock M, Stetefeld J. Matrix Biol. (2012 December)
  • Regulation of the interferon inducible 2’-5’-oligoadenylate synthetase by adenovirus VA(I) RNA. Meng H, Deo S, Xiong S, Dzananovic E, Donald LJ, van Dijk CW, McKenna SA. J Mol Biol. (2012 October)
  • The RNA helicase RHAU (DHX36) unwinds a G4-quadruplex in human telomerase RNA and promotes the formation of the P1 helix template boundary. BooEP, Meier M, Okun N, Novakowsky SK, Xiong S, Stetefeld J, McKenna SA. Nucleic Acids Res. (2012 September)

Honors and Awards

  • 2018 University of Toronto Tri-campus Teaching Excellence Award
  • 2017-2018 University of Toronto Teaching Fellow
  • 2012-2017 Natural Sciences and Engineering Research Council Research Fellow
  • 2012 Society of Chemical Industry Merit Award
  • 2010 Canadian Society for Chemistry Silver Medal